Balaji Narasimhan

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RESEARCH PAGE

Publications

Selected Recent Publications 

• L Liu, MJ Wannemuehler, and B Narasimhan, “Biomaterial nanocarrier-driven mechanisms to modulate anti-tumor immunity,” Current Opinion Biomed Eng 20, 100322 (2021). doi: 10.1016/j.cobme.2021.100322
• S Senapati, RJ Darling, KA Ross, MJ Wannemuehler, B Narasimhan, and SK Mallapragada, “Self-assembling synthetic nanoadjuvant scaffolds crosslink B cell receptors and represent new platform technology for therapeutic antibody production,” Sci Adv 7(32), eabj1691 (2021). doi: 10.1126/sciadv.abj1691
• SM Kelly, KR Larsen, R Darling, BH Bellaire, MJ Wannemuehler, and B Narasimhan, “Single-dose combination nanovaccine induces both rapid and durable humoral immunity and toxin neutralizing antibody responses against Bacillus anthracis,” Vaccine 39(29), 3862-70 (2021)
• LM Stephens, KA Ross, KL Legge, JS McLellan, B Narasimhan, and SM Varga, “Prefusion F-based polyanhydride nanovaccine induces both humoral and cell-mediated immunity resulting in long-lasting protection against respiratory syncytial virus,” J Immunol 206(9), 2122-34 (2021). doi: 10.4049/jimmunol.2100018
• AS Mullis, N Peroutka-Bigus, KS Phadke, BH Bellaire, and B Narasimhan, “Nanomedicines to counter microbial barriers and antimicrobial resistance,” Current Opinion Chem Eng 31, 100672 (2021). doi: 10.1016/j.coche.2021.100672
• BW Schlichtmann, M Hepker, B Palanisamy, M John, V Anantharam, AG Kanthasamy, B Narasimhan, and SK Mallapragada, “Nanotechnology-mediated therapeutic strategies against synucleopathies in neurodegenerative disease,” Current Opinion Chem Eng 31, 100673 (2021). doi: 10.1016/j.coche.2021.100673
• L Liu, P Kshirsagar, J Christiansen, SK Gautam, A Aithal, M Gulati, S Kumar, JC Solheim, SK Batra, M Jain, MJ Wannemuehler, and B Narasimhan, “Polyanhydride nanoparticles stabilize pancreatic cancer antigen MUC4β,” J Biomed Mater Res 109A(6), 893-902 (2021)
• T Mania, E Grego, P Boggiatto, RE Sacco, B Narasimhan, and JL McGill, “Applications of nanovaccines for disease prevention in cattle,” Front Bioeng Biotechnol 8, 608050 (2020). doi: 10.3389/fbioe.2020.608050
• E Grego, A Siddoway, M Uz, L Liu, J Christiansen, SM Kelly, KA Ross, SK Mallapragada, MJ Wannemuehler, and B Narasimhan, “Polymeric nanoparticle-based vaccine adjuvants and delivery vehicles,” Current Topics Microbiol Immunol (2020). doi: 10.1007/82_2020_226
• BW Schlichtmann, N Kondru, M Hepker, AG Kanthasamy, V Anantharam, M John, B Ban, SK Mallapragada, and B Narasimhan, “Enzyme immunoassay-based platform for accurate detection of serum pathological alpha synuclein in Parkinson’s Disease patients,” ACS Chem Neurosci 11, 4179-90 (2020)
• RJ Darling, S Senapati, J Christiansen, L Liu, AE Ramer-Tait, B Narasimhan, and MJ Wannemuehler, “Polyanhydride nanoparticles provide low inflammatory dendritic cell activation and antigen delivery leading to improved CD8+ T cell memory and delayed tumor progression,” Int J Nanomed 15, 6579-92 (2020)
• E Norris, AS Mullis, Y Phanse, LC Bartholomay, B Narasimhan, and JR Coats, “Biodistribution of biodegradable polyanhydride particles in Aedes aegypti,” PLoS Neg Trop Dis 14(9), e0008365 (2020)
• A Thukral, KA Ross, B Narasimhan, H Steinberg, and AM Talaat, “A single dose polyanhydride-based nanovaccine against Johne’s disease,” npj Vaccines 5, 15 (2020). doi: 10.1038/s41541-020-0164-y
• SM Kelly, A Mitra, S Mathur, and B Narasimhan, “Synthesis and characterization of novel rapidly-degrading polyanhydrides as vaccine adjuvants,” ACS Biomater Sci Eng 6, 265-76 (2020)
• DA Wagner-Muniz, SM Kelly, N Peroutka-Bigus, RJ Darling, AC Petersen, BH Bellaire, MJ Wannemuehler, and B Narasimhan, “Single dose combination nanovaccine induces both rapid and long-lived protection against pneumonic plague,” Acta Biomater 100, 326-37 (2019)
• S Dhakal, S Ghimire, S Renu, KA Ross, YS Lakshmanappa, BT Hogshead, P Bernardo, CW Lee, MJ Wannemuehler, B Narasimhan, and GJ Renukaradhya, “Evaluation of CpG-adjuvanted polyanhydride-based intranasal influenza nanovaccine in pigs,” Vet Microbiol 237, 108401 (2019). doi: 10.1016/j.vetmic.2019.108401
• JL McGill, SM Kelly, M Guerra-Maupome, E Winkley, J Henningson, B Narasimhan, and RE Sacco, “Vitamin A deficiency impairs the immune response to intranasal vaccination and RSV infection in neonatal calves,” Sci Rep 9(1), 15157 (2019). doi: 10.1038/s41598-019-51684-x
• EI Wafa, SM Geary, KA Ross, JT Goodman, B Narasimhan, and AK Salem, “Pentaerythritol-based lipid A bolsters the antitumor efficacy of a polyanhydride particle-based cancer vaccine,” Nanomedicine: Nanotechnol Biol Med 21, 102055 (2019). doi: 10.1016/j.nano.2019.102055
• BA Kingstad-Bakke, SS Chandrasekar, Y Phanse, KA Ross, S Marulasiddappa, Y Kawaoka, JE Osorio, B Narasimhan, and AM Talaat, “Effective mosaic-based nanovaccines against avian influenza in poultry,” Vaccine 37, 5051-8 (2019)
• AS Mullis, SR Broderick, AM Binnebose, N Peroutka-Bigus, BH Bellaire, K Rajan, and B Narasimhan, “Data analytics approach for rational design of nanomedicines with programmable drug release,” Mol Pharmaceutics 16, 1917-28 (2019)
• K Banerjee, S Gautam, P Kshirsagar, KA Ross, G Spagnol, P Sorgen, MJ Wannemuehler, B Narasimhan, S Kumar, SK Batra, and M Jain, “Amphiphilic polyanhydride-based recombinant MUC4-nanovaccine activates dendritic cells,” Genes & Cancer 10(3-4), 52-62 (2019)
• SM Kelly, A Upadhyay, A Mitra, and B Narasimhan, “Analyzing drug release kinetics from water-soluble polymers,” Ind Chem Eng Res 58, 7428-37 (2019)
• RJ Darling, S Senapati, SM Kelly, ML Kohut, B Narasimhan, and MJ Wannemuehler, “STING pathway stimulation results in a differentially activated innate immune phenotype associated with low nitric oxide and enhanced antibody titers in young and aged mice,” Vaccine 37(20), 2721-30 (2019)
• M Espinosa-Cotton, SN Rodman, KA Ross, I Jensen, K Miller, AJ McLaren, R Dahl, K Gibson-Corley, V Badovinac, B Narasimhan, and AL Simons, “Interleukin-1 alpha modulates anti-tumor efficacy of cetuximab in head and neck squamous cell carcinoma,” J ImmunoTher Cancer 7, 79-95 (2019)
• S Senapati, RJ Darling, D Loh, IC Schneider, MJ Wannemuehler, B Narasimhan, and SK Mallapragada, “Pentablock copolymer micelle nanoadjuvants enhance cytosolic delivery of antigen and improve vaccine efficacy while inducing low inflammation,” ACS Biomater Sci Eng 5(3), 1332-42 (2019)
• KA Ross, S Senapati, JR Alley, RJ Darling, JT Goodman, M Jefferson, M Uz, B Guo, KJ Yoon, DA Verhoeven, ML Kohut, SK Mallapragada, MJ Wannemuehler, and B Narasimhan, “Single dose combination nanovaccine provides protection against influenza A virus in young and aged mice,” Biomater Sci 7, 809-21 (2019)
• PA Lueth, SL Haughney, AM Binnebose, AS Mullis, ND Peroutka-Bigus, B Narasimhan, and BH Bellaire, “Nanotherapeutic provides dose sparing and improved antimicrobial activity against Brucella melitensis infections,” J Contr Rel 294, 288-97 (2019)
• Z Zacharias, KA Ross, EE Hornick, JT Goodman, B Narasimhan, TJ Waldschmidt, and KL Legge, “Polyanhydride nanovaccine induces robust pulmonary B and T cell immunity and confers protection against homologous and heterologous influenza A virus infections,” Front Immunol 9, 1953 doi: 10.3389/fimmu.2018.01953 (2018)
• TM Brenza, BW Schlichtmann, B Bhargavan, JE Vela Ramirez, RD Nelson, MG Panthani, JM McMillan, B Kalyanaraman, HE Gendelman, V Anantharam, AG Kanthasamy, SK Mallapragada, B Narasimhan, and GD Kanmogne, “Biodegradable polyanhydride-based nanomedicines for blood to brain drug delivery,” J Biomed Mater Res A 106(11), 2881-90 (2018)
• S Renu, S Dhakal, E Kim, JT Goodman, YS Lakshmanappa, MJ Wannemuehler, B Narasimhan, PN Boyaka, and GJ Renukaradhya, “Differential expression of B cell activation factor regulates breadth of antibody responses to nanoparticle-based nasal vaccines,” Cellular Immunol 329, 27-30 (2018)
• JT Goodman, AS Mullis, L Dunshee, A Mitra, and B Narasimhan, “Automated high throughput synthesis of protein-loaded polyanhydride nanoparticle libraries,” ACS Comb Sci 20(5), 298-307 (2018)
• L Sharpe, JE Vela Ramirez, O Haddadin, KA Ross, B Narasimhan, and NA Peppas, “pH-responsive microencapsulation systems for the oral delivery of polyanhydride nanoparticles,” Biomacromolecules 19(3), 793-802 (2018)
• DA Wagner-Muniz, SL Haughney, SM Kelly, MJ Wannemuehler, and B Narasimhan, “Room temperature stable PspA-based nanovaccine induces protective immunity,” Front Immunol 9, 325 doi: 10.3389/fimmu.2018.00325 (2018)
• JL McGill, SM Kelly, P Kumar, S Speckhart, SL Haughney, J Henningson, B Narasimhan, and RE Sacco, “Efficacy of a mucosal, polyanhydride nanovaccine for use against respiratory syncytial virus infection in the neonatal calf,” Sci Rep 8, 3021 doi:10.1038/s41598-018-21292-2 (2018)
• R Schaut, M Brewer, JM Hostetter, K Mendoza, J Vela Ramirez, SM Kelly, J Jackman, G Dell’Anna, JM Howard, B Narasimhan, W Zhou, and DE Jones, A single dose polyanhydride-based vaccine platform promotes and maintains anti-GnRH antibody titers,” Vaccine 36, 1016-23 (2018)
• K Banerjee, S Kumar, KA Ross, B Poelaert, MW Nasser, S Gautam, A Aithal, R Bhatia, MJ Wannemuehler, B Narasimhan, JC Solheim, SK Batra, and M Jain, “Emerging trends in the immunotherapy of pancreatic cancer,” Cancer Lett 417, 35-46 (2018)

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